Changing the content of Сl, Ca, K, Na in the hair of HIV-infected patients depending on the concentration of СD4 lymphocytes
Annotatsiya
Background: A study of the imbalance of macro elemental composition of the HIV infected body is necessary for the understanding of the essence of pathochemical function of the immune system. The purpose of the study is to perform the assessment of certain macro elements in the hair of HIV-infected patients. Methods & Materials: The research examined the macro elemental composition of the hair in 46 HIV-infected patients, 20 healthy individuals, aged 21-54 years, who were at different stages of the infection. All studied patients with HIV infection were registered at the Republican Centre for AIDS Control and Prevention with a confirmed diagnosis. Hair neutron activation method was used to study macro elements in all patients. Patients with HIV - infection were divided into 3 groups depending on the concentration of CD4 lymphocytes: group 1 patients had CD4 lymphocytes concentration >500 cells/μL; group 2 - concentration of CD4 lymphocytes between 200-499 kl/μL; and group 3 - concentration of CD4 lymphocytes <200 cell/μL. Results: The concentrations of Cl, Ca, K were lower in all three groups regardless of the concentration of CD4 lymphocytes. Cl concentration was decreased in all three groups, but the greatest reduction of a factor of two was observed in patients with AIDS. Concentration of Ca has been reduced by half. Na was reduced in 76% of HIV-infected patients, with the largest decline noted in the third group (260 ± 80) (P <0.01). An average decrease in K (140 ± 15 μg/g) by 2.7 times was observed in all three groups of HIV-infected patients; meanwhile, just in the group 1, the potassium concentration decreased by a factor of six. Conclusion: The studies have shown changes in macro elemental composition in the hair of HIV-infected patients. Macro elemental imbalance, which was found in HIV - infected patients in this study, affects the function of the immune system as well as other body systems.