Identification of Bioactive Compounds of the Endophytic Fungus <i>Aspergillus egypticus</i>-HT166S Inhibiting the Activity of Pancreatic α-Amylase
D. M. RuzievaInstitute of Microbiology of the Academy of Sciences, Tashkent, UzbekistanT.G. GulyamovaInstitute of Microbiology of the Academy of Sciences, Tashkent, UzbekistanSaodat NasmetovaInstitute of Microbiology of the Academy of Sciences, Tashkent, UzbekistanIqbol MUKHAMMEDOVInstitute of Microbiology of the Academy of Sciences, Tashkent, UzbekistanGulchehra RasulovaInstitute of Microbiology of the Academy of Sciences, Tashkent, Uzbekistan
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Objectives: . Materials and Methods: The PA inhibitory activity of the secondary metabolites determined using iodometric method. Isolation of inhibitory compounds was carried out by column chromatography, thin layer chromatography and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Results: was 4.82 mg/mL. LC-MS/MS analysis of K-10 showed polymethoxylated flavones (PMF). Conclusion: -HT166S can be considered a source of PMF as potential agents for developing new PA inhibitors.
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