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335 ta ish

Ish: CRISPR-Cas9-Based Technology and Its Relevance to Gene Editing in Parkinson’s Disease

  1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

    Martin Jínek, Krzysztof Chylinski, Ines Fonfara +3

    Maqola20127 iqtibos
    ABI

  2. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

    Valery L. Feigin, Amanuel Alemu Abajobir, Kalkidan Hassen Abate +97

    Maqola20175 iqtibos
    ABI

  3. Multiplex Genome Engineering Using CRISPR/Cas Systems

    Le Cong, F. Ann Ran, David Cox +8

    Maqola20134 iqtibos
    ABI

  4. CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

    Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau +5

    Maqola20074 iqtibos
    ABI

  5. Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

    Kira S. Makarova, Yuri I. Wolf, Jaime Iranzo +23

    Sharh maqola20194 iqtibos
    ABI

  6. Parkinson's disease

    Bastiaan R. Bloem, Michael S. Okun, Christine Klein

    Sharh maqola20214 iqtibos
    ABI

  7. One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

    Haoyi Wang, Hui Yang, Chikdu Shivalila +4

    Maqola20133 iqtibos
    ABI

  8. Incidence of Parkinson's Disease: Variation by Age, Gender, and Race/Ethnicity

    Stephen K. Van Den Eeden

    Maqola20033 iqtibos
    ABI

  9. 53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks

    James M. Daley, Patrick Sung

    Sharh maqola20143 iqtibos
    ABI

  10. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

    Yoshizumi Ishino, Hideo Shinagawa, K Makino +2

    Maqola19873 iqtibos
    ABI

  11. Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

    Lei S. Qi, Matthew H. Larson, Luke A. Gilbert +4

    Maqola20133 iqtibos
    ABI

  12. Delivering CRISPR: a review of the challenges and approaches

    Christopher A. Lino, Jason C. Harper, James P. Carney +1

    Sharh maqola20183 iqtibos
    ABI

  13. DNA targeting specificity of RNA-guided Cas9 nucleases

    Patrick D. Hsu, David A. Scott, Joshua A. Weinstein +11

    Maqola20132 iqtibos
    ABI

  14. CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

    Elitza Deltcheva, Krzysztof Chylinski, Cynthia M. Sharma +6

    Maqola20112 iqtibos
    ABI

  15. A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes

    Daniel H. Haft, Jeremy Selengut, Emmanuel F. Mongodin +1

    Maqola20052 iqtibos
    ABI

  16. Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9

    Taeyoung Koo, Jungjoon Lee, Jin‐Soo Kim

    Sharh maqola20152 iqtibos
    ABI

  17. Genome engineering using the CRISPR-Cas9 system

    F. Ann Ran, Patrick D. Hsu, Jason Wright +3

    Maqola20132 iqtibos
    ABI

  18. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial

    Kevin Fitzgerald, Maria Frank-Kamenetsky, Svetlana Shulga‐Morskaya +17

    Maqola20132 iqtibos
    ABI

  19. RNA-Guided Human Genome Engineering via Cas9

    Prashant Mali, Luhan Yang, Kevin M. Esvelt +5

    Maqola20132 iqtibos
    ABI

  20. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

    Yanfang Fu, Jennifer A Foden, Cyd Khayter +4

    Maqola20132 iqtibos
    ABI

  21. Electrospun biomimetic nanocomposite nanofibers of hydroxyapatite/chitosan for bone tissue engineering

    Yanzhong Zhang, Jayarama Reddy Venugopal, A El-Turki +3

    Maqola20082 iqtibos
    ABI

  22. The blood-brain barrier: Bottleneck in brain drug development

    William M. Pardridge

    Sharh maqola20042 iqtibos
    ABI

  23. Viral vectors: a look back and ahead on gene transfer technology.

    Laura Vannucci, Michele Lai, Flavia Chiuppesi +2

    Maqola20132 iqtibos
    ABI

  24. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

    Daniel G. Healy, Mario Falchi, Sean S. O’Sullivan +22

    Maqola20082 iqtibos
    ABI

  25. Parkinson's disease: clinical features and diagnosis

    Joseph Jankovic

    Sharh maqola20082 iqtibos
    ABI