THE ROLE OF P53 AND BCL-2 GENE EXPRESSION IN BREAST CANCER THERAPY
Annotatsiya
Breast cancer is one of the most common cancers in women. Statistical data of recent years indicate a steady, intensive increase in the incidence and mortality from breast cancer (BC) No specific genetic or epigenetic changes in tumor cells are known that are responsible for their aggressive behavior the process of metastasis, which is the main cause of death in cancer patients. An important role in the occurrence and development of breast cancer of the p53 gene, which protects the body from mutant cells, has been noted. Mutations in the p53 gene allow cells with damaged DNA to maintain mitotic activity. The incompleteness of apoptosis explains the different tumor sizes, non-invasive and slow tumor growth. The bcl-2 gene, in turn, suppresses cell apoptosis. The bcl-2 protein plays a key role in the regulation of apoptosis. Based on the foregoing, the analysis of the expression of the p53 gene, the bcl-2 proto-oncogene and the dependence of their expression on various factors during tumor formation are an important pathophysiological characteristic.