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Bioactive Evaluation of Naringenin in Ameliorating Hyperuricemia‐Induced Liver Injury by Inhibiting Xanthine Oxidase

Xiaoyue ZhangDepartment of Pathology The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Clinical Pathology, Shandong Lung Cancer Institute, Shandong Institute of Nephrology Jinan Shandong ChinaLinfeng LiuInstitute of Foof & Nutrition Science and Technology Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro‐Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences Jinan Shandong ChinaZhaosen FanBenon Biological Shandong Benon Biological Technology Co. Ltd. Heze ChinaNilufar Z. MamadalievaInstitute of the Chemistry of Plant Substances Institute of the Chemistry of Plant Substances of the Academy Sciences of Uzbekistan Tashkent UzbekistanChao LiuInstitute of Foof & Nutrition Science and Technology Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro‐Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences Jinan Shandong ChinaXu GuoInstitute of Foof & Nutrition Science and Technology Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro‐Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences Jinan Shandong ChinaShutao SunInstitute of Foof & Nutrition Science and Technology Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro‐Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences Jinan Shandong ChinaHui SunCollege of Food Science and Engineering Ocean University of China Qingdao Shandong ChinaNingyang LiCollege of Food Science and Engineering Ocean University of China Qingdao Shandong ChinaMiaofen WangInstitute of Foof & Nutrition Science and Technology Key Laboratory of Novel Food Resources Processing, Ministry of Agriculture and Rural Affairs/Key Laboratory of Agro‐Products Processing Technology of Shandong Province, Shandong Academy of Agricultural Sciences Jinan Shandong China

eFoodjournal2025en

ABI

Annotatsiya

ABSTRACT Hyperuricemia (HUA) is one of main risk factors for liver injury, and xanthine oxidase (XOD) is an important target for HUA‐induced liver injury. As a typical natural active ingredient, naringenin (NAR) has been confirmed the good therapeutic effect on variety of diseases. However, studies of NAR ameliorating HUA‐induced liver injury have not been reported. Therefore, we evaluated the bioactivity of NAR in ameliorating HUA‐induced liver injury and investigated the related molecular mechanisms. The inhibitory activity and type of NAR on XOD was investigated by enzymatic reactions and kinetic analyses, and molecular docking showed that NAR was able to bind tightly to XOD. In vivo activity studies showed that NAR ameliorated liver function while being able to inhibit XOD activity. NAR alleviated oxidative stress in the liver caused by excess reactive oxygen species through antioxidant activity. At the same time, NAR exerted anti‐inflammatory activity by regulating the levels of inflammatory factors. The molecular docking results suggested that NAR was able to interact with Keap1 and AMPK to exhibit antioxidant and anti‐inflammatory effects. This work demonstrated the therapeutic effect of NAR on HUA‐induced liver injury, which was valuable for the further development of related functional foods.

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Mavzular

Gout, Hyperuricemia, Uric Acid Alcohol Consumption and Health Effects Diet, Metabolism, and Disease

Identifikatorlar

DOI: 10.1002/efd2.70032

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