Synthesis and biological activity

351 works

Design, combinatorial synthesis and cytotoxic activity of 2-substituted furo[2,3-d]pyrimidinone and pyrrolo[2,3-d]pyrimidinone library
Buer Song, Lifei Nie, Khurshed Bozorov +3
ArticleSynthesis and Biological EvaluationMolecular Diversity202219 citations
ABI
Synthesis of Substituted Thieno[2,3‐d]pyrimidin‐4‐ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models
Khurshed Bozorov, Nilufar Z. Mamadalieva, Burkhon Elmuradov +5
ArticleSynthesis of heterocyclic compoundsJournal of Chemistry201218 citations
ABI
Design, synthesis, in vitro evaluation of a new pyrrolo[1,2‐a]thiazolo[5,4‐d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease
Yan Zeng, Lifei Nie, Liu Liu +6
ArticleCholinesterase and Neurodegenerative DiseasesJournal of Heterocyclic Chemistry202217 citations
ABI
Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties
Khurshed Bozorov, Jiang-Yu Zhao, Burkhon Elmuradov +2
Review articleQuinazolinone synthesis and applicationsEuropean Journal of Medicinal Chemistry201514 citations
ABI
Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1
Khurshed Bozorov, Hairong Ma, Jiangyu Zhao +7
ArticleSynthesis and biological activityEuropean Journal of Medicinal Chemistry201411 citations
ABI
A Convenient One-pot Synthesis of 2,3-Disubstituted Thieno[2,3-d]pyrimidin-4(3H)-ones from 2H-Thieno[2,3-d][1,3]oxazine-2,4(1H)-diones, Aromatic Aldehydes and Amines
Feize Liu, Xueling Hou, Li Fei Nie +3
ArticleQuinazolinone synthesis and applicationsSynOpen201811 citations
ABI
Synthesis and anticancer activity of ethyl 5‐amino‐1‐N‐substituted‐imidazole‐4‐carboxylate building blocks
Zukela Ruzi, Lifei Nie, Khurshed Bozorov +2
ArticleSynthesis and Characterization of Heterocyclic CompoundsArchiv der Pharmazie202111 citations
ABI
<scp>2‐substituted</scp> tricyclic oxazolo[5,4‐d]pyrimidine library: Design, synthesis, and cytotoxicity activity
Yan Zeng, Lifei Nie, Khurshed Bozorov +4
ArticleQuinazolinone synthesis and applicationsJournal of Heterocyclic Chemistry202111 citations
ABI
Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2
Khurshed Bozorov, Jiang Zhao, Li Fei Nie +7
ArticleClick Chemistry and ApplicationsRSC Advances201710 citations
ABI
Synthesis of tricyclic pyrazolopyrimidine arylidene ester derivatives and their cytotoxic and molecular docking evaluations
Tong Lu, Lifei Nie, Danling Tang +3
ArticleSynthesis and biological activityJournal of Heterocyclic Chemistry202410 citations
ABI
Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure–Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico
Azizbek Azamatov, Sherzod Zhurakulov, Валентина И. Виноградова +6
ArticleSynthesis and Biological ActivityMolecules20239 citations
ABI
Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action
Zukela Ruzi, Khurshed Bozorov, Lifei Nie +2
ArticleSynthesis and biological activityBiomedicine & Pharmacotherapy20228 citations
ABI
Chemical transformations of mackinazolinone and its derivatives
Azizbek Nasrullaev, Ж. Э. Турдибаев, Burkhon Elmuradov +3
ArticleQuinazolinone synthesis and applicationsChemistry of Natural Compounds20128 citations
ABI
Reaction of 2,3-tetramethylen-3,4-dihydroquinazol-4-one and its derivatives with aromatic aldehydes and furfurol
А. Ш. Абдуразаков, Burkhon Elmuradov, Ж. Э. Турдибаев +1
ArticleQuinazolinone synthesis and applicationsChemistry of Natural Compounds20098 citations
ABI
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview
Khurshed Bozorov, Jiangyu Zhao, Haji Akber Aisa
Review articleClick Chemistry and ApplicationsBioorganic & Medicinal Chemistry20197 citations
ABI
Synthesis of 6-benzylaminopurine and the study of biological active properties of cotton C-6424 plants
Gulbakhar Baymuratova, Khasan Nasimov, Foziljon Saitkulov
ArticleSynthesis and biological activityE3S Web of Conferences20237 citations
ABI
Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release
Ping Zhou, Yoshihisa Takaishi, Hong‐Quan Duan +6
ArticlePlant chemical constituents analysisPhytochemistry20007 citations
ABI
Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and ADME/T studies
Mohamed Rbaa, Asmaa Oubihi, Halima Hajji +7
ArticleSynthesis and biological activityJournal of Molecular Structure20217 citations
ABI
Analgesic and Anti-Inflammatory Effects of 1-(4'-Dimethylaminophenyl)-6, 7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
Khilola A. Rakhmanova, Sherzod Zhurakulov, Firuza M. Tursunkhodjayeva +2
ArticleChemical synthesis and pharmacological studiesBiomedical & Pharmacology Journal20227 citations
ABI
2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry
Khurshed Bozorov, Li Fei Nie, Jiangyu Zhao +1
Review articleSynthesis and biological activityEuropean Journal of Medicinal Chemistry20176 citations
ABI
2-Methyl-4-oxo-6,7,8,9-tetrahydrothieno[2′,3′:4,5]pyrimidino[1,2-a]pyridine-3-carboxylic acid
Burkhon Elmuradov, Khurshed Bozorov, R. Ya. Okmanov +2
ArticleCrystal structures of chemical compoundsActa Crystallographica Section E Structure Reports Online20116 citations
ABI
Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one as DDR2 kinase inhibitor: Synthesis, molecular docking, and anticancer properties
Zukela Ruzi, Khurshed Bozorov, Lifei Nie +2
ArticleSynthesis and biological activityBioorganic Chemistry20236 citations
ABI
Synthesis of Novel 7-Phenyl-2,3-Dihydropyrrolo[2,1-b]Quinazolin-9(1H)-ones as Cholinesterase Inhibitors Targeting Alzheimer’s Disease Through Suzuki–Miyaura Cross-Coupling Reaction
Davron Turgunov, Lifei Nie, Azizbek Nasrullaev +7
ArticleCholinesterase and Neurodegenerative DiseasesMolecules20255 citations
ABI
1H NMR spectra and crystal structure of the nickel(II) complex with ethyl 5,5-dimethyl-2,4-dioxohexanoate aroylhydrazones
М. А. Турсунов, К. Г. Авезов, B. B. Umarov +1
ArticleSynthesis and Characterization of Heterocyclic CompoundsRussian Journal of Coordination Chemistry20175 citations
ABI
Tetraaquabis[2-(2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)acetato]zinc
Jamshid Ashurov, Gavhar Karimova, Н. С. Мухамедов +2
ArticleCrystal structures of chemical compoundsActa Crystallographica Section E Structure Reports Online20115 citations
ABI

Synthesis and biological activity

Design, combinatorial synthesis and cytotoxic activity of 2-substituted furo[2,3-d]pyrimidinone and pyrrolo[2,3-d]pyrimidinone library

Synthesis of Substituted Thieno[2,3‐<i>d</i>]pyrimidin‐4‐ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models

Design, synthesis, in vitro evaluation of a new pyrrolo[1,2‐<i>a</i>]thiazolo[5,4‐<i>d</i>]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease

Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties

Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: Synthesis and in vitro biological evaluation. Part 1

A Convenient One-pot Synthesis of 2,3-Disubstituted Thieno[2,3-d]pyrimidin-4(3H)-ones from 2H-Thieno[2,3-d][1,3]oxazine-2,4(1H)-diones, Aromatic Aldehydes and Amines

Synthesis and anticancer activity of ethyl 5‐amino‐1‐<i>N</i>‐substituted‐imidazole‐4‐carboxylate building blocks

<scp>2‐substituted</scp> tricyclic oxazolo[5,4‐<i>d</i>]pyrimidine library: Design, synthesis, and cytotoxicity activity

Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2

Synthesis of tricyclic pyrazolopyrimidine arylidene ester derivatives and their cytotoxic and molecular docking evaluations

Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure–Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico

Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action

Chemical transformations of mackinazolinone and its derivatives

Reaction of 2,3-tetramethylen-3,4-dihydroquinazol-4-one and its derivatives with aromatic aldehydes and furfurol

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview

Synthesis of 6-benzylaminopurine and the study of biological active properties of cotton C-6424 plants

Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release

Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and ADME/T studies

Analgesic and Anti-Inflammatory Effects of 1-(4'-Dimethylaminophenyl)-6, 7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride

2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry

2-Methyl-4-oxo-6,7,8,9-tetrahydrothieno[2′,3′:4,5]pyrimidino[1,2-<i>a</i>]pyridine-3-carboxylic acid

Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one as DDR2 kinase inhibitor: Synthesis, molecular docking, and anticancer properties

Synthesis of Novel 7-Phenyl-2,3-Dihydropyrrolo[2,1-b]Quinazolin-9(1H)-ones as Cholinesterase Inhibitors Targeting Alzheimer’s Disease Through Suzuki–Miyaura Cross-Coupling Reaction

1H NMR spectra and crystal structure of the nickel(II) complex with ethyl 5,5-dimethyl-2,4-dioxohexanoate aroylhydrazones

Tetraaquabis[2-(2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)acetato]zinc