Effects of Fermentation Conditions on the Production of Secondary Metabolites of Penicillium brevicaule alba-CC200 and Aspergillus egypticus–HT166 Inhibiting Pancreatic α-Amylase
T. G. GulyamovaInstitute of Microbiology of the Academy of Sciences RU, UzbekistanD. M. RuzievaDepartment of Biochemistry and Biotechnology of Physiologically Active Compounds,S. M. NasmetovaDepartment of Biochemistry and Biotechnology of Physiologically Active Compounds,I. I. MuhammedovDepartment of Biochemistry and Biotechnology of Physiologically Active Compounds,G. A. RasulovaInstitute of Microbiology of the Academy of Sciences RU, UzbekistanРано СаттароваInstitute of Microbiology of the Academy of Sciences RU, Uzbekistan
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Abstract
Carbon and nitrogen sources were selected to create a new modified Chapek-Doks nutrient medium in order to increase the production of secondary metabolites, that inhibit pancreatic α-amylase, by endophytic fungi Penicilliumbrevicaule alba-CC200 and Aspergillus egypticus-HT166. The results showed that the highest α-amylase inhibitory activity - 96.8% and 88%, respectively, was observed during the shake flask cultivation of strains at the end of the stationary phase on a medium containing casein supplemented by yeast extract.
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