Maqola

GLC-MS profiling of non-polar extracts from Phlomis bucharica and P. salicifolia and their cytotoxicity

Nilufar Z. MamadalievaInstitute of the Chemistry of Plant Substances AS RUz, Laboratory of the Chemistry of Glycosides, Tashkent, UzbekistánVittorio VinciguerraTuscia University, Department for the Innovation in Biological, Agro-food and Forestal Systems, Viterbo, ItaliaMansour SobehHeidelberg University, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Baden-Wurttemburg, AlemaniaElisa OvidiTuscia University, Department for the Innovation in Biological, Agro-food and Forestal Systems, Viterbo, ItaliaMohamed L. AshourHeidelberg University, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Baden-Wurttemburg, AlemaniaMichaël WinkHeidelberg University, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Baden-Wurttemburg, AlemaniaAntonio TiezziTuscia University, Department for the Innovation in Biological, Agro-food and Forestal Systems, Viterbo, Italia

Redalyc (Universidad Autónoma del Estado de México)repository2015en

ABI

Annotatsiya

"Phlomisspecies (Phlomis bucharicaRegel and P. salicifoliaRegel) have been traditionally used by Uzbek people as stimulant, tonic, diuretic, and in the treatment of ulcers, hemorrhoids, wounds and gynecological problems. In the present study, we characterized the chemical composition of non-polar extracts from P. bucharicaand P. salicifoliaby high resolution GLC-MS and evaluated their cytotoxicity. Concentrations of hexadecanoic acid in hexane and chloroform extracts were higher in P. bucharicathan in P. salicifolia. 1,8-Cineol, camphor, borneol, α-terpinol, thymol, and isobornyl acetate were detected in P. bucharicabut not in P. salicifolia. About 45 components were identified in P. bucharicaand 40 in P. salicifolia. The chloroform extract from P. bucharicashowed cytotoxicity in HeLa and HL-60 cells, with IC50values of 26.07 and 29.42 μg/ml, respectively."

Mavzular

Phytochemistry and Biological Activities Chromatography in Natural Products Flavonoids in Medical Research

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