Мақола

The Structural Changes in the Membranes of Staphylococcus aureus Caused by Hydrolysable Tannins Witness Their Antibacterial Activity

Ewa Olchowik‐GrabarekLaboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, 15-245 Bialystok, PolandSzymon SękowskiLaboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, 15-245 Bialystok, PolandAgnieszka KwiatekDepartment of Molecular Virology, Institute of Microbiology, Faculty of Biology, University of Warsaw, 02-096 Warsaw, PolandJagoda PłaczkiewiczDepartment of Molecular Virology, Institute of Microbiology, Faculty of Biology, University of Warsaw, 02-096 Warsaw, PolandNodira AbdulladjanovaInstitute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent 100143, UzbekistanVadim ShlyonskyLaboratory of Physiology and Pharmacology, Faculty of Medicine, Université libre de Bruxelles, 1070 Brussels, BelgiumIzabela ŚwięcickaLaboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, 15-245 Bialystok, PolandMaria ZamaraevaLaboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, 15-245 Bialystok, Poland

Membranesjournal2022en

ABI

Аннотация

Polyphenols, including tannins, are phytochemicals with pronounced antimicrobial properties. We studied the activity of two hydrolysable tannins, (i) gallotannin—1,2,3,4,5-penta-O-galloyl-β-D-glucose (PGG) and (ii) ellagitannin—1,2-di-O-galloyl-4,6-valoneoyl-β-D-glucose (dGVG), applied alone and in combination with antibiotics against Staphylococcus aureus strain 8324-4. We also evaluated the effect of these tannins on bacterial membrane integrity and fluidity and studied their interaction with membrane proteins and lipids. A correlation between the antimicrobial activity of the tannins and their membranotropic action depending on the tannin molecular structure has been demonstrated. We found that the antibacterial activity of PGG was stronger than dGVG, which can be associated with its larger flexibility, dipole moment, and hydrophobicity. In addition, we also noted the membrane effects of the tannins observed as an increase in the size of released bacterial membrane vesicles.

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Мавзулар

Tannin, Tannase and Anticancer Activities Protein Hydrolysis and Bioactive Peptides Phytochemicals and Antioxidant Activities

Идентификаторлар

DOI: 10.3390/membranes12111124

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